The Incidence Risk Factors And Prognosis Of Acute Kidney Injury In Severe And Critically Ill Patients With Covid-19 In Icu Of Eka Kotebe Hospital Addis Ababa Ethiopia A Retrospective Chart Reviews.

Abstract rnBackground-The incidence, clinical characteristics and outcomes of acute kidney injury (AKI)rnin patients with COVID-19 admitted to intensive care unit and its association with mortality andrndisease severity. rnObjective-To determine the incidence, risk factors, clinical characteristics and outcomes of AKIrnin a cohort of patients with COVID-19 admitted to Eka Kotebe Intensive Care Unit (ICU), andrnits association with in-hospital mortality(survival), dialysis requirement, increased need ofrnmechanical ventilation, disease severity and renal status at discharge. rnMethods- It’s a single centered cohort study from a registry of patients with COVID-19. A totalrnof 174 patients were admitted to medical ICU with confirmed COVID-19 between from 1strnOctober 2020 to 31 may 2021. We classified AKI by comparing highest to lowest recordedrnserum creatinine in hospital and staged AKI based on the Kidney Disease: Improving GlobalrnOutcomes (KDIGO) system. We calculated the unadjusted and adjusted odds ratio for the stagernof AKI and the need for mechanical ventilation, and in-hospital mortality. rnMeasurements-Stage of AKI, LOS, mechanical ventilation, discharge, and in-hospital mortality.rnResults-Of the total 174 patients registered to the log book during the study time, and only 156 rnpatients were found to be eligible for study and from this 95(60.9%) developed AKI, 36 (37.9%)rnpresented with AKI, and 59 (62.1%) developed AKI in-hospital. High charlson comorbidityrnindex, low lymphocyte count, low serum albumin level, higher white blood cell counts andrnSerum alkaline phosphatase measurement, vasopressor need for life support, and mechanicalrnventilation were found to be associated significantly with increased risk for AKI. rnLimitations-a cohort study with small sample size limits precision of estimates. Lack of nonhospitalizedrnrnand stable admitted patients with confirmed COVID-19 as controls limits causalrninferences. rnConclusions-Acute kidney injury, whether it occurs prior to or after hospitalization, is associatedrnwith a high risk of poor outcomes in patients with COVID-19. Routine assessment of kidneyrnfunction in patients with COVID-19 may improve risk.

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