This study has investigated factors affecting economic empowerment of indigenous people inrnGambella regional state with the case study of three zones (Nuer, Anyua, and Majang Zone). Thernstudy was conducted through descriptive analysis survey design by using both quantitative andrnqualitative research methods. Both primary and secondary data have been utilized. The techniquernof taking sample from the given population is purposive sampling drawing a sample ofrn180 people from the population of 307,096people. Data was analyzed using statistical figurernsuch as tables, graphs, pie charts, and percentages, is employed.rnFinding revealed that economic empowerment of the local people is negatively affected by thernfactors of cultural of dependency in both urban and rural community and weak policies formulatedrnimplementation of the regional government. Study regarding Organizational Availabilityrnshows that Organizational Availability is not yet established in Gambella except micro and smallrnenterprises. In general statements, Indigenous people are from respondents confirmed that economicallyrnpoor with the reasons which are associated to the factors such as cultural influence,rnfinancial limitation, lack of awareness creation by the regional government, and some more explanatoryrnvariables which are shown in the above analysis. Moreover, weak policies formulationrnand their implementation, issue such as economic prioritization, and absent of micro enterprisesrnagencies effective role in the region have been identified as the undermining factors in lesseningrnthe empowerment of the local people significantly.rnThe study recommended that Regional Government need to create favorable environment thatrnpromotes innovation and entrepreneurial development, and formulation of correct poliCies whichrncould solve public problems inclusively.