Humanitarian supply chain collaborations are a vital cluster of activities during emergenciesrndue to natural or man-made disasters to prevent loss of lives and property and alleviaternsuffering in unstable environments. However, the subject is not well studied compared to thernbusiness collaborations in profit-making organizations where profit is their main reason forrnexistence. The main objective of this study was to assess the practices, challenges, drivers,rnand performances of selected non-profit making International and local Non-Governmentalrnorganizations of the Eritrean refugee crises in Ethiopia and try to contribute to the researchrnfamily in the field. The main research designs applied for the research were descriptive andrnexplanatory types of research design. The data was collected through a questionnaire andrndistributed to 100 selected staff and partners from Addis Ababa the country office staffs, andrnTigray region field offices in Mekelle, sub-office Shire, and Sheraro zone staffs where therernhosts a lot of Eritrean refugees which call upon emergency activities from international NonGovernmental organizations and local Non-Governmental organizations. Out of the 100rndistributed questionnaires only 80 were used for the analysis as the remaining 20 were eitherrnrejected for incompleteness or not returned at all. The data collected were analyzed throughrnthe computer software SPSS and presented using descriptive texts, frequency tables, crosstabulations, percentiles, means, standard deviations, correlation, and regressions. Thernassessment of the Humanitarian supply chain collaboration practices revealed that NonGovernmental organizations assess mutual trust well by building trustworthiness among localrnand international Non-Governmental organizations in the affected area and the reciprocalrncommitment and relationship-specific investment activity is also managed well. The resourcerncomplementarity, strategic compatibility, and long-term orientation of resource sharing inrnmultiple events are also at its well level though there is some reservation indicated in thernresponses. Operational compatibility, relational, and coordination capability in deliveringrnefficient relief were found to be satisfactory with some remarks. Searching for to get reducerncosts, eliminate duplications, attracting more donors from the drivers and poorrncommunication, power imbalance, absence of mutuality from challenges are mentioned to bernthe main factors affecting the performances of the organization. In general, the collaborationrnbetween international Non-Governmental organizations and local Non-Governmentalrnorganizations in the Eritrean refugee crises in Ethiopia is operating well in the mentionedrnareas and the activities are found to be fairly properly managed. However, the challenges andrndrivers should be seriously considered and need to be dealt with the organizations for thosernchallenges and drivers in the control of the organizations while discussion with partners andrnthe responsible government bodies are required for those beyond control. Flexibility at jointrnplanning and forecasting is crucial and hence a contingency plan needs to be applied by thernorganization as flexibility is perceived to be not performing well. As a future direction forrnresearchers interested in this field, it is good to consider more organizations especially on therndyadic and network relationships that affect their performances in different regions.rn.