The World Health Organization (WHO) defines access to medicine as a priority for citizens. Itrnneeds to be available at all times in adequate amounts, in appropriate dosage and quality and atrnan af ordable price for individuals and communities. To ensure that people have access tornessential and quality medicines, a functioning and sustainable supply chain is necessary. Thernstudy aimed at assessing the challenges of pharmaceuticals supply chain management in Publicrnhealth facilities in west Shewa zone, Oromia region -Ethiopia. Descriptive type of research withrnmixed research approaches were employed to investigate the challenges of pharmaceuticalrnsupply chain management. The data was collected by using structured questionnaire from fortyrnhealth facilities (three hospitals and 37 health centers). The questionnaires were provided tornpharmacy section heads, laboratory section heads and store managers of the selected healthrnfacilities and five key informants were interviewed by using interview guide from zonal healthrndesk, hospital and health center. The health facilities were classified by their type of facilitiesrnand each health facility was selected by using lottery method. The data collected from 40 healthrnfacilities and analyzed by using descriptive statistics. From the finding of the study the humanrnresource, financial resource and infrastructure and information technology challenges werernidentified. It was concluded that human resources identified to be one of the importantrnchallenges in pharmaceutical supply chain management. Lack of adequate financial allocationrnwas major challenges in financial resources which limit availability of essential pharmaceuticalsrnto provide basic service at facility level. From the study it was also found that there wererninadequacies of storage spaces with substandard shelves. It is better to solve human resource, financial resource and infrastructure and information technology challenges through training ofrnmanpower, using revolving drug funds and renovation of warehouses consecutively .