The main objective of the study was to assess pharmaceuticals procurement practices andrnchallenges of Ethiopian Pharmaceuticals supply agency. The study was conducted to examinernthe practices of good pharmaceuticals procurement practices, procurement planning, supplierrnrelationship management practices and most procurement challenges of the agency. Descriptivernresearch design was used in executing the study. The targeted group of the study wasrnprocurement staffs who are working on procurement process.57 staff members were participatedrnin this particular study, purposive sampling techniques was used to select number of samples.rnPrimary data was collected using questionnaire and interview guidelines. Based on this,rnmajority of the respondents was strongly agreed (43.9%) that all products are procured withrntheir generic names. 70.2% of the respondents said that procurement is made fromrnpharmaceuticals procurement list of the agency. 52.6% of respondents disagreed on thernstatement that requested quantities for procurement are based on reliable estimate of actualrnneed. More than half of the respondents (50.9%) said that there is a high level of commitmentrnbetween the agency and its suppliers but 54.4% of the respondents replied that the agency didnâ€™trnclassify its suppliers based on a well-defined set of criteria. The most top pharmaceuticalsrnprocurement challenges of EPSA were lengthy procurement process, inaccuraternquantification/forecast data, weak collaboration with stakeholders, delay funding allocation orrnrelease and Inadequate rules, regulations, and structures for pharmaceuticals procurement.rn.