Background: Neisseria meningitides represents a pathogen of great public health importance inrnboth developed and developing countries. Resistance to some antimicrobial agents used eitherrnfor therapy of invasive infections or for prophylaxis of case contacts has long been recognized.rnHowever, there is a limited data in relation with the antimicrobial resistance pattern of Neisseriarnmeningitides in Ethiopia. Therefore; the aim of this study was to assess drug susceptibilityrnpattern of Neisseria meningitides isolates from asymptomatic carrierers of all age groups atrnMeskan and Mareko Districts, Gurage Zone, Southern Nations, Nationalities and PeoplesrnRegional State Ethiopia.rnMethods: Cross-sectional study was conducted on 187 Neisseria meningitides isolates obtainedrnfrom MenAfricar project.A total of 4110 study participants from Meskan and Mareko Districts,rnGurage Zone, Southern Nations, Nationalities and Peoples Regional State, Ethiopia werernscreened for Neisseria meningitides by the project. Antimicrobial susceptibility test (AST) wasrndone on stored Neisseria meningitides isolates.The activity of ten antimicrobial agents used forrntreatment and prophylaxis of meningococcal disease was investigated. The AST was performedrnfor Neisseria meningitides isolates according to the criteria of the CLSI guide line by diskrndiffusion method. Data was analysed by using SPSS version 20.0 software.rnResults: From 187 Neisseria meningitides isolates 8(4.28%) were serogroup X, 24(12.83%)rnwere serogroup Y, 1(0.53%) was serogroup W135 and 154(82.35%) were non determinant (ND).rnResistance for Cotrimoxazol was high accountingrn116(62%)rnfollowed by Ciprofloxacinern112(60%), Cefotaxime 26(14%), Ceftriaxone 24(13%) , Meropenenem 21(11%) , Minocyclinern15(8%), Rifampine 14(7.5%), Azithromycine 10(5%), Chloramphenicol 7(4%),Levofloxacinrn6(3%) . 102(54.5%) isolates were resistance for more than one drug.rnConclusions: An antimicrobial resistance for Neisseria meningitides isolates from asymptomaticrncarriers for the present study is high. Continued surveillance of meningococci for antimicrobialrnresistance is necessary to monitor early detection of changes in susceptibility patterns that mightrnaffect recommendations for chemoprophylaxis and treatment.rnKey words: Neisseria meningitides, serogroups, sensitivity pattern, drug resistance