Sero-prevalence Of Hbv And Hcv Among Chronic Liver Disease Patients Visiting Opd In Public Hospitals In Addis Ababa Ethiopia

Background: Hepatitis B and C viruses (HBV & HCV) are hepatotropic viruses causing viralrnhepatitis, chronic liver disease and hepatocellular carcinoma. Hepatitis B and C virus infectionsrnare still major public health problems around the globe. Both of these viruses are transmittedrnmainly through the parenteral route and therefore a dual infection of these viruses can occurrnand even persists in the same patient. They are prevalent in different parts of the world includingrnEthiopia. In view of this, the present study was designed to determine the prevalence of HBV andrnHCV infection and co-infection in clinically diagnosed chronic liver disease patients who visitedrnpublic hospitals of Addis Ababa.rnObjective: The objective of this study was to determine the prevalence of HBV and HCVrninfection among chronic liver disease patients who visited public hospitals of Addis Ababa,rnEthiopia.rnMethod: Hospital based cross-sectional study was conducted in three public hospitals of AddisrnAbaba over a period of 7 months (Nov 2010- May 2011) on clinically diagnosed chronic liverrndisease patients. By using questionnaire brief history and risk factors were taken from eachrnvolunteering patient. Serum samples from each volunteering patients was screened for thernpresence of HBsAg and anti-HCV Ab by using qualitative rapid test kits.rnResult: A total of 120 participants who have chronic liver disease participated in the study,rnwhere 76 of them were males and the remaining 44 were females. The age distribution rangernform 18-80 years and the mean age was 40.99 years ±14 SD. The overall prevalence of HBsAgrnand HCV was 35.8% and 22.5% respectively. The prevalence of HBsAg and anti-HCV Ab wasrnhigh in age below 50 years. 2.5% of the study participants had combined HBV/HCV infectionrnwhich is possible because of their common modes of transmission.rnConclusion: The prevalence of HBV and HCV in chronic liver disease patients is high andrndental extraction at health facility was statistically associated with HCV infection.rnKey words: Hepatitis B virus, Hepatitis C virus, chronic liver disease, prevalence, co-infection

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