Prevalence Of Autoimmune Hemolytic Anemia In Hiv Infected Anemic Adults A Cross Sectional Study At Tikur Anbessa Specialized Teaching Hospital From June 5 2015 To September 10 2015 Addis Ababa Ethiopia

Background:- Hematologic manifestations in HIV/AIDS positive patients are many. A highrnprevalence of anemia and significantly reduced white blood cell and neutrophil counts werernobserved in HIV-infected individuals. Presence of auto antibody also contributes for therndevelopment of anemia in HIV positive individuals. Few studies are conducted to show thernprevalence of anemia in HIV positive individuals, but there is no documented data that rule outrnthe prevalence of AIHA in HIV positive individuals in Ethiopia.rnObjective:- To determine the prevalence of autoimmune haemolytic anemia in HIV-infectedrnadult patients at Tikur Anbessa Specialized teaching Hospital, Addis Ababa, Ethiopia.rnMethods:- Hospital based cross sectional study was conducted on 384 HIV positive individualsrnusing convenient sampling method at Tikur Anbessa Hospital from June 5, 2015 to Septemberrn10, 2015. Participants’ soco-demographic data, CD4 result and some important information wasrnextracted from participants’ records; from patient card and request paper using Microsoft excel.rnAnd 5 ml of venous blood was collected for determination of HGB, RBC count, RBC indices,rnreticulocyte count and other CBC results. After all, DAT was performed and blood filmrnexamination was done to confirm hemolysis. Finally data was imported and analyzed using SPSSrnversion 16 statistical soft ware package, and Descriptive statistic and Chi-square tests were used.rnResult:- Of 384 study participants, 9 (2.34 %) patients are found to be AIHA positive. Of these,rn6 (66.7 %) were females and 3 (33.3 %) were males. Nineteen patients had positive DAT result;rn10 (52.6 %) had mild anemia, 4 (21 %) moderate and 5 (26.3 %) severe anemia respectively. 37rn(9.6 %) patients showed reticulocytopinea, while 31(8.1 %) patients had shown reticulocytosis.rnFrom 26 patients who showed evidence for the presence of hemolysis in their blood film, twornindividuals showed +2 graded hemolysis whereas 24 patients showed +1 graded hemolysis.rnConclusion:- Prevalence of AIHA in HIV patients is not common. AIHA can be an etiologicalrncause of anemia most of the time in patients with severe-moderate ranged anemia and in patientsrnwith low CD4 count.rnAutoimmunernhaemolyticrnanemia,rnreticulocytosis.rnrndirectrnanti-globulinrntest,rnhemoglobin,

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