Background: In Ethiopia there are large numbers of plants having medicinal values; among them arernAlbizia gummifera and Millettia ferruginia. The effect of seeds extracts of these plants on bloodrnparameters and organs such as heart and small intestine is not fully investigated.rnObjective: This study aimed to evaluate the sub-chronic toxic effects of hydro-ethanolic (70%) seedrnextracts of A. gummifera and M. ferruginea on the heart, small intestine and on some blood parameters inrnalbino wistar rats.rnMethod: Seeds were collected from different areas of Ethiopia. They were dried and crushed to powderrnand macerated with hydro-alcohol and placed in orbital shaker. The extract was then filtered, evaporated torndryness by Rota vapor and further concentrated by water bath at 40oc. The gummy residue extract wasrnweighed and packed in air tight brown glass bottles with proper label and kept at 4 Oc. The sample size forrnthe study was 158 rats.To determine the LD50 of the extract, 108 female rats were treated with differentrndoses of the extracts. For the sub-chronic toxicity study, 50 rats (25 male and 25 female) werernadministered at doses of 125 mg/kg/day and 250 mg/kg/day for 90 days. Hematological analysis wasrnperformed usingautomatic hematology analyzer, cell-DYN-3700 (Abbott Diagnostic Division, USA) andrnclinical chemistry analyzer, Human star 80 (Human GmbH, Germany) was used to determine biochemicalrnparametrs. Data was cleaned, entered and analyzed using SPSS 16.Finally, the animals were quicklyrndissected. Heart and small intestine were carefully removed. Portions of these organs were fixed in 10%rnformalin for histopathological examination.rnResult: The LD50 of A. gummifera and M. ferrugina were found to be 4000 mg/kg and 3500 mg/kg,rnrespectively. The seed extract of A. gummifera decreased the MCH (P