Serum Total And Placental Alkaline Phosphatas At Second And Third Trimesters Of Normal Pregnant Mothers From July To Nov 2015 At Zewditu Memorial Hospital Addis Ababa Ethiopia

Background: Alkaline phosphatase (ALP) (EC 3.1.3.1.) is an enzyme which catalyzes thernhydrolysis of phosphate esters at an alkaline PH. Placental alkaline phosphatase isoenzymern(PLAP) has several vital roles during pregnancy for supporting fatal growth and development.rnThe change of PLAP may be associated with high blood pressure, preterm delivery and otherrncomplication. It could be an indicator of overall placental performance and pregnancy outcomes.rnTherefore, there is the need to determine and proper interpretation in our local setup.rnObjectives: To evaluate serum total and placental alkaline phosphatase at second and thirdrntrimesters in normal pregnant mothers in our local setup.rnMethod: Across-sectional study was done on randomly selected 333 consenting apparentlyrnhealthy pregnant mothers at Zewditu Memorial Hospital in Addis Ababa, Ethiopia. Maternalrndemographic characteristic was obtained through questionnaires and medical chart review. ThernTALP and PLAP were analyzed by Human 4-Nitrophenylphosphatas (4-NPP) substrate. Therndata was analyzed using the SPSS software, version 21. The data was assessed using non-rnparametric analysis; hence the data was found to be skewed. P< 0.05 was considered statisticallyrnsignificant.rnResult: The median of TALP and PLAP in second trimester were ( 163 IU/L) and (25 IU/L)rnrespectively while in third trimester were (334 IU/L) and (141IU/L) respectively and at termrnwere (449 IU/L) and ( 230 IU/L) respectively (P< 0001). Strong positive correlation observedrnbetween TALP (r2 = 0.805, p

Get Full Work

Report copyright infringement or plagiarism