Background: Robust l aboratory c ommodities i nventory management pr actices pr ovide c urrentrninformation on quantities of laboratory commodities consumed as well as enables to accuratelyrnestimate requirements for future use. A poorly functioning laboratory inventory management canrnlead to frequent stock outs leading to services interruptions or overstock.rnObjective: The aim of this study is to assess the status of laboratory inventory management andrnknowledge, attitude and practices of professionals at Tikur Anbessa specialized hospital (TASH).rnMethods: A cross-sectional descriptive study was conducted to assess the practices of laboratoryrncommodities in ventory management a t TASH from M ay t o J une 2016. Both qua ntitative a ndrnqualitative data collection techniques were used.rnResults: The ove rall s tock out of l aboratory commodities on t he da y of t he s tudy was 44rn(37.0%). These stock o uts included S erology 27 (84.4%), Clinical Chemistry 13 ( 28.9%),rnHematology 3 (20%), and Urine analysis 1 ( 33.3%). Moreover, there was no expired laboratoryrncommodity during th e s tudy p eriod in th e me dical s tore. In a ddition, there were no s tock out srn(0.0%) for bacteriology and parasitology reagents on the day of the study and during the past onernyear p eriod. On t he ot her ha nd, during t he p ast one year time ; t he ov erall s tock out w as 55rn(46.2%). Of t hese 27 (84.4%) of serology, 24 (53.4%) of chemistry, 3 (20%) of hematologyrnand1 ( 33.3%) of urinalysis laboratory c ommodities were s tock out during t he pa st one yearrnperiod. S ome of t he reasons m entioned b y respondents f or s tock out i ncluded w eak s election,rnquantification, pr ocurement a nd i n a dequate s tock c ontrol a nd m anagement,rndelay i n t hernpurchasing procedure; weak/unknown consumption data; absence in the supply agency PFSA tornavail ne eded l aboratory c ommodities; s hortage of bud get; unpr edicted s ervices d emand orrnincreased p atient f low; and short e xpiry. On t he assessment o f stock m anagement, 81 (97.6%)rnrespondents knew the appropriate storage of at room temperature, cold chain items, and frozenrnitems. Majority 80 (96.39%) of the respondents knew the importance of separation of flammablernchemicals, da mage or e xpired pr oducts removed f rom s tock r ecords. A ll ( 100%) of t hernrespondents ha ve t he d esired pr actices as r egards t o t he ne ed for cleaning and de forestingrnrefrigerators a nd prevent f rom s unlight a nd w ater pe netration a nd m ore ove r 97.6% of t hernrespondents have the good practices of separately storing of rapidly deteriorating of laboratoryrncommodities.rnConclusion: Although there were no expired items during the past year; frequent stock outs werernreported f or di fferent l aboratory s ervices a nd s upplies at T ASH. Therefore capacity b uildingrntraining of the staff on selection and quantification, inventory management and storage practicesrnof laboratory commodities may be necessary to sustainably overcome the frequent stock out andrninterruption in service.rnKey word: Laboratory inventory management, Tikur Anbessa specialized hospital, laboratoryrnCommodity