Association Of Intestinal Helminth Infection With Atopy And Allergic Symptoms In Young Children In Batu Ethiopia

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Background: Helminths are potent immunomodulators and chronic infections may protect againstrnallergy-related disease and atopy. They are also known for inducing allergic conditions. This study wasrnaimed to assess the association between helminths and atopy and allergic conditions.rnObjective: To assess the association between intestinal helminth infection and atopy/allergic outcomesrnin young children in Batu, Ethiopia.rnMethods: Questionnaire data on allergic symptoms and a range of confounding variables was gatheredrnin a cross-sectional study of 461 children aged from 2 to 14 years from Batu. Allergic skin sensitizationrnto house dust mite and cockroach was measured, and a stool sample collected for qualitative andrnquantitative geohelminth analysis. Serum IgE using ELISA and Manual eosinophil count werernmeasured. Data was entered and analyzed using SPSS version 20.rnResults: Overall sensitivity to both allergens was 2.6 %. Self - reported allergic outcomes in the lastrn12 months for the 461 participants had been; wheeze (3.7%), asthma (2.2%), eczema (13.2%), and hayrnfever (6.9%). A burden of 8.1% (36/444) was recorded for helminths. A borderline significantrnassociation was found between atopy and any allergy symptoms [OR 3.32 (95% CI: 0.99, 11.1), P =rn0.052]. There was no significant association between helminths and atopy [OR 0.64 (95% CI: 0.29,rn1.41) p = 0.268] and also between helminths and allergic symptoms [OR 0.64 (95% CI: 0.29, 1.41) prn= 0.268]. Bivariate analysis showed keeping animas in the house associated with atopy while maternalrnand paternal history of allergy associated with allergic symptoms in the children.rnConclusion: Contrary to the majority of related studies that reported a positive or negative associationrnbetween helminths and allergy-related outcomes, we found no relation between the two. Furtherrnlongitudinal studies are warranted to further elucidate the controversy.rnKeywords: Atopy, helminths, Allergy, IgE

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Association Of Intestinal Helminth Infection With Atopy And Allergic Symptoms In Young Children In Batu Ethiopia

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