Prognostic Importance Of Lactate Dehydrogenase And Uricaacid As Compared To Breakpoint Cluster Region-abelson Transcript Level Among Chronic Myeloid Leukemia Patients In Tikur Anbessa Specialized Teaching Hospital Addis Ababa

Background: Chronic myeloid leukemia (CML) is characterized by the presence of Philadelphiarn(Ph) chromosome, which results from by the breakpoint cluster region-Abelson (BCR-ABL)rnfusion gene. Increasing levels of BCR-ABL are strongly predictive of cytogenetic andrnhematologic relapse. However, this molecular test for BCR-ABL is readily available in therndeveloped world and rarely available in low and middle-income countries, which is also limitedrnin access and very expensive to afford. As a result of this, serum LDH and uric acid estimations,rnwhich are easily available and cost effective, have gained considerable appreciation as valuablernprognostic markers of CML.rnObjectives: To evaluate prognostic importance of total LDH and uric acid as compared tornbreakpoint cluster region-Abelson (BCR-ABL) transcript level in chronic myeloid leukemiarn(CML) patients among treated and treatment naive patients.rnMethods: A cross- sectional study was carried out from January to March 2017 at TikurrnAnbessa specialized hospital in Addis Ababa. Convenient sampling method was used to includerneighty one (81) CML patients from those who came for testing GeneXpert RT-PCR transcriptrnlevel. We studied the correlation between LDH with BCR-ABL and hematological parametersrnusing spearman correlation, Mann-Whitney U test and roc curve data analysis tool.rnResult: A total of 81 CML patients were assayed 46(56.8%), medication treated group and thernremaining 35 (43.2%) are treatment naive patients. Significant positive correlations werernobserved between LDH and BCR-ABL (r=0.79, P

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