Serological And Molecular Characterization Of Hepatitis B C And D Viruses Infections Among Health Professionals In Ras Desta And Tikur Anbessa Hospitals Addis Ababa Ethiopia

The risks for occupational infection with blood-borne pathogens (HBV, HCV, and HIV) havernbeen a source of concern among health professionals because of their frequent and oftenrnsubstantial exposures to patient blood and body fluids and all of which are associated withrnsignificant morbidity and mortality. A cross sectional study was conducted in order to assess thernprevalence of HBV, HCV, and HDV infections among HCW’s (n=267) and risk factorsrnassociated with these viral infections. After each volunteer study subject has completed arnstandardized questionnaire, 10 ml of venous blood was collected from each individual forrnserological and molecular processing. ELISA method was used to detect HBs and HBe antigens,rnantibodies to HBc, HBs, HDV and HCV in the serum samples. Molecular methods were used torndetect HBV DNA and HCV RNA. One hundred and eight (40.4%) of the health professionals userngloves consistently, 221 (82.3%) had at least a one time history of cutaneous exposure to bloodrnungloved, 165 (61.8%) of health care workers had at least a one time history of cutaneousrnexposure to any of the body fluids, 162 (60.6%) had splashed blood or body fluids in their faces,rn158 (59.2 %) had sustained needle stick injury and 83 (31.1%) sustained sharp injury. The overallrnprevalence of HBV infection was found to be 51.3% (95% CI: 45-57%) and the infectionrnprevalence increases with age (p

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