Background: Hepatitis B virus (HBV) and hepatitis C virus (HCV) are hepatotropic viruses whosernprimary replication occurs in the liver. A range of extrahepatic manifestations such as arthralgias,rnthyroiditis and diabetes are linked with HCV infections. Patients with diabetes mellitus arernpredisposed to develop a spectrum of liver diseases.rnObjective: To determine the burden of Hepatitis B and Hepatitis C virus and their associatedrnFactors among diabetes patients attending University of Gondar Referral Teaching Hospital,rnNorthwest Ethiopia.rnMethods: A comparative cross sectional study design was employed on 305 diabetes and 305rndiabetes free individuals from October 2016 to February 2017. Pre-tested structured interviewerrnbased questionnaire was used to collect data. Blood specimen was collected and serum wasrnseparated to determine hepatitis B surface antigen (HBsAg) and anti-HCV by Enzyme linkedrnimmunosorbent Assay (ELISA) assay. Data were entered with epidata; then exported to, clearedrnand analyzed by the statistical software SPSS version 20. Univariable and multivariable logisticrnregression analyses were performed to identify factors that contribute to the occurrence ofrnHepatitis B and Hepatitis C viral infections. Statistical significance was considered whenever p-rnvalue was less than 0.05.rnResult: Out of the total, 10.7% was found to be positive for Hepatitis infections, of which 14.43rn% and 6.89% study participants were sero-positive for at least one of the viruses in diabetes andrncontrol groups respectively. The sero-positivity of Hepatitis B was 8.5% and 4.6% (95% CI, 0.96rn- 4.02); and Hepatitis C viral infections 7.5% and 2.3% (95%CI, 1.46 - 8.68) in diabetes and controlrngroups respectively. History of blood transfusion (95% CI, 1.36 - 12.71) and unprotected sex (95%rnCI, 1.25 - 10.15) were found to be significantly associated with HBsAg sero-positivity and type ofrndiabetes (95% CI, 1.25 - 10.89) was independently associated with anti-HCV seropositivity.rnConclusion and recommendation: Even though no statistically significant difference detected inrnHBV infection, the sero-positivity against anti- HCV antibody in diabetes and controls groups wasrnfound to be 7.5% and 2.3%, respectively and the difference was statistically significant (p-value