Serum Level Of -hcg In Normotensive And Pre-eclamptic Pregnant Women Attending Antenatal Care At Tikur Anbessa Specialized Hospital A Case-control Study

Background: Pre-eclampsia remains a major cause of prenatal morbidity and mortalityrnworldwide. WHO estimated the incidence to be seven times higher in developingrncountries (2.8% of live births) than in developed countries (0.4%). Overall, pre-eclampsiarnConclusion: The study found out a significantly higher serum level of β-hCG inrnmultigravida pre-eclamptic women than in normotensive ones. It also found out arnsignificantly higher level of β-hCG in primigravida than in multigravida normotensivernwomen. Early onset pre-eclamptic group had higher level of β-hCG than late onset pre-rneclamptic group.rnKey words: Pre-eclampsia, human chorionic gonadotropinrnrnand eclampsia accounts for 10%–15% of maternal deaths. Early identification of pregnantrnwomen at risk for pre-eclampsia is a priority to implement preventive measures. So farrndelivery is the only curative treatment. It is postulated that pre-eclampsia is likely to be arntrophoblastic disorder. Since β-hCG is secreted by trophoblastic cells its serum level mayrnbe essential in diagnosing the disease.rnObjective: To assess the association between maternal serum level of β-hCG and pre-rneclampsiarnMethods: A case control study was conducted on a total of 76 pregnant women withrnsingleton pregnancies attending antenatal clinic during the period from June, 2013 tornMarch, 2014 at Tikur Anbessa Specialized Hospital. Thirty eight normotensive pregnantrnwomen were grouped in controls and thirty eight pregnant women with pre-eclampsiarnwere grouped in the cases. Serum level of β-hCG was determined by thernelectrochemiluminescence immunoassay (ECLIA) using cobas e 411 immunoassayrnanalyzer. T-test, nonparametric tests and regression analysis were used for statisticalrnanalysis. A level of P< 0.05 was considered statistically significant.rnResult: The mean level of maternal serum β-hCG in the pre-eclamptic group wasrnsignificantly higher than in the normotensive group (34439.18 ± 28223.67 Vs. 20582.00rn± 17588.31, p=0.012). However, significant difference was found only in multigravidarnwomen. Early onset pre-eclamptic group had higher mean level of β-hCG than late onsetrngroup but this was not statistically significant (p=0.539). Unlike the pre-eclamptic group,rnprimigravida normotensive group had significantly higher serum β-hCG concentrationrnthan multigravida ones (p=0.026). Concentration of β-hCG was positively correlated withrndiastolic, systolic and mean arterial blood pressure (r= 0.23, 0.05, 0.15 and p= 0.17, 0.79rnand 0.36 respectively) and negatively correlated with maternal age, gestational age andrnparity (r= -0.15, -0.21, -0.06 and p= 0.36, 0.20 and 0.71 respectively

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