Background: Work-related disorders are the major causes for complaints and disability inrnworking populations. Globally 2 million occupational fatalities occur across the world everyrnyear. In sub-Saharan Africa, the fatality rate per 100,000 workers is 21. Respiratory disordersrnare among the most common occupational diseases. Although cleaning represents a significantrnpart of the working population worldwide, it is a relatively understudied occupation. Thernalterations of pulmonary function of professional cleaners in hospitals have not been addressedrnpreviously in Ethiopia.rnObjectives: The aim of this study was to assess the pulmonary functions and respiratoryrnsymptoms of cleaners working in hospital setting.rnMethod: A comparative cross sectional study design was employed on 140 study participants.rnThe study was composed of 70 cleaners and 70 control subjects working in Tikur Anbesa,rnZewditu and Yekatit 12 hospitals in Addis Ababa, Ethiopia. Respiratory symptoms (cough,rnwheezing, Breathlessness, and chest pain) were assessed using standardized questionnaire.rnSpirometer was also used to measure pulmonary function. The data was coded, entered, cleanedrnand analyzed using SPSS version 20.rnResults: The mean age of cleaners and controls were 28±7.40 and 28.33±7.44 respectively. Thernmean of BMI for cleaners was 22.68±3.25 while for control group was 22.66±2.96. The risk ofrndeveloping respiratory symptoms were higher among cleaners than controls (p