Gastric hyperacidity and peptic ulcer are very common causes of human suffering in this erarnof globalization. Treatment of peptic ulcer is targeted at either counteracting aggressivernfactors or stimulating the mucosal defenses. Natural products from bees and plants arernrecently becoming the focus of attention as preventive medicine in providing protectionrnagainst acute and chronic gastric lesions. In the present study, the gastroprotective effects ofrnethanol extract of propolis (EEP) from Ethiopian central high land was evaluated againstrnethanol and indomethacin-induced gastric ulcers in mice. Half kilogram of propolis wasrnsoaked in 70% ethyl alcohol for two weeks at room temperature with intermittent shakingrntwice a day. After evaporating the alcohol and lyophilizing the residue to dryness, a gummyrnconsistent crude propolis extract of 35.35g yield was obtained. The phytochemical screeningrnwith thin layer chromatography (TLC) and gas chromatography-mass spectrometry (GC/MS)rnshowed that the major phyto-constituents of the extract were amryn type triterpenic alcoholsrn(26.2%), sugars (24.9%) and fatty acids (7.5%), with significant amount of aromatic acids,rnesters and other alcohols including diterpenic alcohol. Swiss albino mice of 24-32g bodyrnweight were fasted for 24hours and pretreated with varying doses of EEP or standard drugsrn(omeprazole or cimetidine) fifty minutes before ulcer induction either with alcohol orrnindomethacin. In alcohol-induced ulcers, EEP at doses of 25, 50 and 100mg/kg significantlyrnreduced lesion index and number of the total lesions (P