Pulmonary Function Tests Among Pregnant Women Of Different Trimester In Debere Berhan Referal Hospital Shoa Ethiopia

Introduction: Pregnancy is characterized by sequence of dynamic physiological changes thatrnimpact on multiple organ system functions. The increasing size of the fetus with advancingrngestation and associated hormonal changes constitute a mechanical impediment to normal process ofrnmaternal ventilation. As the uterus expands, the diaphragm is pushed up as much as 4 centimeter.rnPrecise knowledge of the pulmonary function test parameters helps to understand and manage therncourse and outcome of pregnancy leading to safe delivery. It also helps to avoid misdiagnosis andrnunnecessary interventions.rnObjective: The aim of this study was to determine the effect of normal pregnancy on pulmonaryrnfunction tests among women that visit Antenatal care clinic in Debere Berhan Referral Hospital,rnEthiopia.rnMethods: Comparative cross-sectional study design was used in Debere Berhan referralrnHospital. A total of 176 study participants were enrolled by convenience sampling technique andrncategorized in to four groups (those in their first, second and third trimesters, and control). Eachrngroup comprised of 44 study participants. Written consent was obtained; anthropometric data,rnsaturation of arterial blood and pulmonary function testes were collected using height and weightrnmeasuring scales, pulse oximetery (Oxi-Max N-65), and spiropro® (Courtesy of Jaeger/CardinalrnHealth, Hochberg, Germany) respectively. Data was tabulated and analyzed using SPSS versionrn20.0 statistical software.rnResults: Mean of FVC for the controls, first, second, and third trimesters were (2.59 ± 0.26, 2.13 ±rn0.15, 1.93 ± 0.27, and 1.90 ± 0.11 liters) respectively. Except similar FEV1%, the mean value ofrnFVC, FEV1, PEFR, and FEFrn25-75%rnin pregnant group (at all three trimesters) were significantlyrndecreased from the controls (P

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