Seroprevalence Of Hepatitis B And C Virus And Occult Hepatitis B Among Blood Donors At National Blood Bank Addis Ababa Ethiopia

Background: Transfusion associated hepatitis B and C viral infection continues to be a major problem in developing countries, even after the adoption of mandatory screening for HBsAg by ELISA method. This is mainly because of the blood from the donors with ‘occult’ HBV infection which is defined as viral DNA without detectable HBsAg observed after the initial period of primary infection and most of the time accompanied by the presence of anti-HBc.rnObjective: To assess Seroprevalence and associated risk factors of Hepatitis B and C Virus and Screening of Occult Hepatitis B among Blood Donors at National Blood Bank, Addis Ababa, EthiopiarnMethods: A cross-sectional study was conducted on 2977 volunteer blood donors from April to Jun 2017. All donors’ blood were screened for HBV and HCV with ELISA technique. For occult HBV, 391 blood samples which were found to be negative for all transfusion transmissible infections (TTIs) (for HIV, HCV, HBV and Syphilis) were taken and analyzed for anti-Hepatitis B core total (IgG and IgM) using Architect Chemiluminecent Micro particle Immunoassay (CMIA) technique. Socio demographic and associated risk factors were gathered using predesigned questions. Bivariate and multivariate logistic regression analyses were used to quantify the effect of different risk factors on hepatitis B and C infections. P values

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