Introduction: -Accumulating evidence indicates that schizophrenia is accompanied by anrnactivation of the immune/inflammatory system. But there is limited data from low and middleincomerncountries like Ethiopia. Inflammatory markers may even be more important in thesernsettings where infectious conditions may have more prominent role in the causation andrnmaintenance of schizophrenia.rnObjective: - To assess the level of inflammatory markers in patients with schizophrenia.rnMaterials and methods - The level of inflammatory markers among patients withrnschizophrenia were compared with non-affected control groups. The study population consistedrnof a total 132 study participants, including 82 with schizophrenia and 50 control subjects. Highrnsensitive C-reactive protein (hsCRP) and Interleukin-6(IL-6) were measured using Cobas e 411rnand Cobas Intgera 400 Plus analysers at EPHI. Linear regression was used to adjust forrnconfounders in estimating the level of inflammatory markers. The study was conducted fromrnJanuary 2015 to March 2016.rnResults: - The levels of hsCRP were significantly increased in patients with schizophrenia whenrncompared to control groups (B=; 95% CI=; p=0.003), and also there were significantrndifferences in IL-6 were found in the patients with schizophrenia when compared control groupsrn(B=; 95% CI=; p=0.002).Controlling for age, sex and body mass index, having a diagnosticrnschizophrenia was the most important factor associated with increased IL-6 and hsCRP.rnConclusion: - Higher levels of both hsCRP and IL-6 appear to be associated withrnschizophrenia, suggesting a role for the inflammatory process in the pathophysiology ofrnschizophrenia. Further investigation using larger sample size are warranted. Clinical trials ofrninterventions to decrease inflammation are worth considering.