Establishment Of Reference Intervals For The Common Renal And Liver Function Clinical Chemistry Parameters Among Apparently Healthy Pregnant And Non-pregnant Women In South Wollo Zone Amhara National Regional State Northeast

Background: Physiological changes during pregnancy causes alterations in biochemicalrnanalytes concentration. Thus, pregnancy specific reference intervals (RI) are important forrnaccurate diagnosis and treatment of cases. In Ethiopia, clinical laboratory test results arernusually interpreted using values established on western population.rnObjective: To establish RIs for common renal and liver function clinical chemistryrnparameters among apparently healthy pregnant and non- pregnant women in South wollornzone, Amhara National Regional State, northeast Ethiopia.rnMethods: A community based cross sectional study was conducted on a total of 378rnapparently healthy study participants randomly selected from south wollo zone, Ethiopiarnfrom April to June 2019. Data like medical history, physical examination and sociodemographyrnwere collected by using well organized questionnaire. After the exclusion ofrnoutliers using quartile method, Kolmogorov–Sminorv test was used to check its normality.rnThe 95% RI with 95% confidence interval was established using the non-parametricrnmethod. The significance of differences between pregnant and non-pregnant women wasrnevaluated using Mann–Whitney U test.rnResult: There was statistically significant variation between pregnant and non-pregnantrnwomen in values of Albumin, T.Protein, ALP, urea and Creatinine but not for AST, ALT,rnbilirubin(direct) and bilirubin(total). Reference intervals established for pregnant womenrnincludes: albumin 26.14–42.87g/l, total protein 48.52–74.71 g/l, AST 2.4–43.6 U/L, ALTrn0.94–28.35 U/L, ALP 21.2–337 U/L, bilirubin(direct) 0.03-0.32 mg/dl, bilirubin(total) 0.26-rn0.94 mg/dl, creatinine 0.29–0.87 mg/dl, urea 7.17–20.82 mg/dl. Albumin: 32.81–47.87,rntotal protein: 56.71–83.9 U/L, AST: 4.2–37.1 U/L, ALT: 2.69–41.18 U/L, ALP: 3.22–278.7rnU/L, bilirubin(direct) 0.1-0.51mg/dl, bilirubin(total) 0.24-1.06mg/dl, creatinine 0.44–1.00rnmg/dl, urea 8.07–27.87 mg/dl for non-pregnant women.rnConclusion: The RIs provided by this study are decisive in interpreting clinical laboratoryrnresults for medical decision making and other health-related conditions. Physiologicalrnadaptations of pregnancy should be taken into account when interpreting LFT and RFT in arnpregnant woman.

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