Background: Breast cancer (BC) is a type of cancer that develops/grows in breast tissues. It isrnone of the leading causes of death among women worldwide. Breast cancer is the most frequentrncancer and the second leading cause of cancer death among women in industrialized countries.rnAlthough it is curable if diagnosed and treated appropriately at an early stage of the disease,rndiagnosis remains a challenge to the clinicians. The value of current histological prognosticrnindicators in predicting the course of the disease is weak and reliable markers are still lacking.rnTherefore, these gaps have led to significant interest in the quest for minimally invasive markersrnthat are sensitive enough to detect early the presence of tumours in patients but not in healthyrntumour-free individuals. rnObjective: was to investigate the capability of circulating microRNAs in serum to discriminaternbreast cancer patients from healthy controls. rnMethods: The study was conducted from June 2017 to August 2018 at Tikur AnbessarnSpecialized University Hospital.A case control study design was conducted involving 50rnparticipants (25 cases, 25 controls). Five milliliter of blood samples were collected and serumrnwas separated from each patient and healthy controls. miRNAs were extracted from serumrnsamples and their relative expression levels were determined by quantitative real time PCR. Datarnwere analyzed using SPSS software (version 25.0, Chicago, IL, USA) and Graph pad Prismrnversion 7. After CT values were analyzed using Microsoft Excel 2010, independent t test and onernway ANOVA was done to assess significance of the difference between patients and controls.rnData were presented as mean Â± SD. Values were considered statistically significant when Pvaluernwasrnless thanrn0.05.rnrnResults: We reported that breast cancer specific circulating miRNAs level showed significantrndifference in breast cancer patients as compared to healthy controls. The expression level ofrnmiR-21 and miR-195 were significantly higher (P=0.003, P=0.042 respectively) in serum ofrnbreast cancer patients than healthy controls. While there was no significant difference inrnexpression of miR-145 and miR-130b.Furthermore we showed that miR-21 and miR-195rnexpression level were higher in surgical operated breast cancer patients. Conclusion: Circulating miR-21 and miR-195 are potential breast cancer biomarkers for breastrncancer.