Establishment Of Hematological Parameters Reference Intervals For Apparently Healthy Adolescents In Asella Town South East Ethiopia

Background: -Physicians' medical decisions are based on information provided by laboratoryrnreports in the form of a reference interval (RI) or medical decision limit. The interval serves as arnhealth-related standard with which to compare an individual test result. However, the lack ofrnbringing up as its own standard, local reference values has been a problem facing hematologicalrnpractice in our country.rnObjective: To establish hematological parameters reference intervals for apparently healthyrnadolescents (12-17) in Asella town, South East Ethiopia from January to March 2020 GC.rnMethod: A total of 342 apparently healthy adolescents aged 12–17 years living in Asella town andrnfulfilling the eligibility criteria were recruited for this cross-sectional descriptive study using arnsystematic random sampling method. Data including socio-demographic characteristics wererncollected using a structured questionnaire. The hematological analysis was performed usingrnSysmex KX-21 3 Diff analyzer. Data was entered and analyzed using SPSS version 21. The nonparametricrnMann-Whitney u test was used to compare the parameters between genders. The 97.5rnpercentile and 2.5rnthrnpercentile as the upper and Lower Reference limit in favor of the adolescentrnpopulation were determined.rnResult: The study observed statistically significant mean differences between males and femalesrnin Hemoglobin (HGB), Hematocrit (HCT), Mean cell hemoglobin concentration (MCHC), MeanrnCell volume (MCV), absolute lymphocyte number (LYM#), Red Blood Cell (RBC), and Redrnblood cell distribution width by the coefficient of variation (RDWCV). Whereas the mean valuesrnof other Hematological parameters like WBC PLT and RWDSD have no significant differencernbetween bothrnsex (p value>0.05). Hence the reference interval of White Blood Cells (WBC), Platelet (PLT) andrnRed blood cell distribution width by the standard deviation (RWDSD) in adolescents were (3.410.rn9x103/ul), (153.9-390x103/ul) and (36.8-47.1fl) respectively. The current established referencernintervals show higher proportions out of range values when compared to the existing referencernintervals.rnConclusion: Some hematological parameter showed a significant difference in the mean valuesrnamong data sets for HGB, RBC, MCV and MCHC across gender (p value

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