Study Of Significance Of Platelet Count In Prognosis Of Pregnancy-induced Hypertension At Mizan-tepi University Teaching Hospital South-west Ethiopia.

Background: Pregnancy-induced hypertension (PIH) is defined as hypertension that occurs inrnpregnancy for the first time in a previously normotensive woman after 20 weeks of gestation andrndisappears following delivery. It is one of the leading causes of maternal and fetal morbidity andrnmortality globally. It accounts for about 14% of maternal death globally. rnObjective: The objective of this study was to assess the significance of platelet count in thernprognosis of pregnancy-induced hypertension. rnMethods: A comparative cross-sectional study was conducted at Mizan-Tepi University TeachingrnHospital from January 2020 to March 2020. The study was conducted among 60 studyrnparticipants; 30 healthy normotensive pregnant women and 30 women with PIH. Face-to-facerninterview using structured questionnaire, physical examination, and review of medical records wasrnused for data collection. Blood pressure readings were taken while the woman was relaxed andrnseated in the upright position using a mercury sphygmomanometer apparatus from thernparticipant’s left hand. An approximately 3ml venous blood was collected into a vacutainer tubernand analyzed in a hematology auto analyzer within 30 minutes of blood collection to determine thernvalue of the platelet count. Statistical data analysis was done using independent t-test, linearrnregression, and one-way ANOVA supplemented with post hoc multiple comparisons by SPSSrnversion 21 software, and P ≤ 0.05 was considered as statistically significant. The receiverrnoperating characteristics (ROC) curve was used to determine the optimal cut-off point of plateletrncount for the prediction of the development of PIH. rnResult: The mean age of the case and control groups of the study participants was 27.93(±5.80)rnand 26.43(±4.99) years which has an insignificant difference (p=0.287, >0.05). Among womenrnwith PIH 3(10%) of them had eclampsia, 19(63.4%) had pre-eclampsia, and 8(26.6%) hadrngestational hypertension. From women with PIH, 9(30%) of cases had mild forms and 21(70%) ofrncases had severe forms of PIH. The mean arterial blood pressure of the case and control subjectsrnwas 122.92(±11.20) and 81.17(±6.46) and for a mild and severe form of the case, the meanrnarterial blood pressure was 111.44(±4.16) and 127.84 (±9.51) mm Hg respectively. The meanrnplatelet count in the case was found to be 154.87(±42.56)×10rn3rn/µL with a range of 73-232×10rn/µLrnwhile in controls the mean platelet count was 273.47(±34.08)×10rn3rn/µL with a range of 223337×10rn3rn/µL which showed a decrement of platelet count in cases as compared to that in controlsrnand this difference was statistically significant (p=0.000,

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