Background: Hepatitis B virus (HBV) infection is globally recognized as a major risk factor forrnthe development of liver cirrhosis and hepatocellular carcinoma in hyper endemic areas. Thoughrnsome evidences shows that the association of HBV with other infections like H pylori andrnintestinal parasite is described in some places such information is lacking in Ethiopia. rnObjective: To determine magnitude of Hepatitis B Surface Antigen positivity rate and itâ€™srncomorbidity with intestinal parasites and Helicobacter pylori infections among School Childrenrnin Ziway, central Ethiopia rnMethods: Both retrospective and prospective cross-sectional study was conducted fromrnOctober 2018 to January 2019 on samples collected from Ziway children aged 2-14 years.rnSocio-demographic and data related to intestinal parasites and Helicobacter pylori infectionrnwere collected from a data base which has been establi shed from a previous project. HBVrnsurface antigen tests were performed on 348 sera using the Enzyme Linked ImmunosorbentrnAssay (ELISA).Some socio demographic data, H.pylori status and intestinal parasitesrnburden were taken from previous data base . Data was analyzed using SPSS version 20.rnDescriptive statistics was employed to determine proportions. Chi square test was employedrnto see any relation between HBV and demographic variables. Result was consideredrnstatistically significant at p < 0.05. rnResults: Out of 348 children, 179 (51.4%) were females. Most were in the age group between 59rnyearsrnandrnaccountingrn49.6%rnofrntherntotalrnschoolrnchildren.rnAboutrn31.9rn%rn(111/348)rnmothersrnhadrnrnnon-formalrnrneducation and 152 mothers (44.0 %) were housewives. The overall magnitude ofrnHBsAg among school children was 3.74 % (13/348). The magnitude was higher in children agedrn10-14 years (5.5%) and in males (4.2 % vs 3.4% in females), though not statistically significant.rnAmong 324 serum samples analyzed, 235(72.5%) were positive for H. pylori antibody, 25% hadrnprotozoa and 9 % had helminthes. Neither H pylori antibody nor intestinal parasites wererndetected in the 13 HBsAg sero positive school children. rnConclusion: Though we used a single marker for HBV infection, it calls for further studies tornassess the real burden of HBV infection in the study sites. Health education should be given forrnthe school communities and families of students to increase awareness and take preventivernmeasures towards HBV infection.