Background: Recently there is an epidemiological transition in global health fromrncommunicable to NCDs. Common preventable risk factors underlie most NCDs and physicalrninactivity is identified as the fourth leading risk factor for NCDs. Bank employees arernsusceptible to NCDs associated with their physical inactivity. rnObjective: The aim of this study is to compare BMI, blood pressure and blood glucose levelrnbetween bank employees and daily laborers in Addis Ababa, Ethiopia. rnMethods: A comparative cross-sectional study design was carried out involving a total ofrn192 adult study participants (96 permanent bank employees and 96 daily laborers working atrnconstruction sites). Data was collected by a structured questionnaire, physical and fastingrnblood glucose measurements. Independent t-test, chi-square test and multivariable linearrnregression were used to compare and examine the associations of physical activity with BMI,rnblood pressure and blood glucose level. rnResults: Compared to daily laborers bank employees had significantly higher means ofrnsystolic blood pressure (p < 0.001), diastolic blood pressure (p < 0.001) and fasting bloodrnglucose (p < 0.001). Mean BMI was slightly higher in bank employees than daily laborers,rnbut was not significantly different (p = 0.106). For both bank employees and daily laborers,rntotal physical activity and meeting WHO recommendation on physical activity werernsignificantly associated with systolic blood pressure and diastolic blood pressure (P < 0.001).rnWe found no significant association of total physical activity with blood glucose (p = 0.059).rnThe association of BMI with total physical activity was negative for bank employees andrnpositive for daily laborers. rnConclusion: The higher means of systolic blood pressure, diastolic blood pressure, BMI andrnblood glucose level in bank employees showed the negative impact of physical inactivity onrncardiovascular system, body composition and metabolism. rnRecommendations: We recommend that promoting active lifestyles should be a nationalrnpublic health priority by targeting sedentary workers.