Background: Hepatitis B and C viruses are the leading causes for global morbidity and mortality of viral hepatitis.rnAccording to the world health organization report, globally an estimated 257 million and 150 million people arernliving with chronic HBV and HCV respectively. The risk of these infectious blood borne pathogens are highest onrnthe health care settings and the health care workers or people who work in the field of medicine are at highest riskrnfor these infections. In Ethiopia, although reports showed that more than 60% of chronic liver disease and up to 80%rnof hepato-cellular cancers have occurred due to hepatitis B and C viral infections, still there is limited surveillancerndata regarding the impacts of these infectious pathogens among the health care workers and the impact of hepatitisrnwas totally neglected among the traditional healers. So far in Ethiopia, very limited studies were conducted to showrnthe prevalence and risk factors of hepatitis among allopathic health care workers. Yet, no studies have beenrnconducted to show the burdens of hepatitis and risk factors among traditional healers. Therefore, further studiesrnshould be conducted to show the impact of hepatitis among the healers alongside the aliphatic health care workers.rnObjective: the aim of this study was to assess the sero-prevalence and associated risk factors of hepatitis B and Crnamong the health care workers and the traditional healers at selected study sites of Kolfe-Keraniyo sub city AddisrnAbaba Ethiopia.rnMethod: An institution based cross-sectional study was conducted from the study period of November,rn2017toJanuary; 2019.Study participants were selected using a multi-stage sampling technique. A multi-itemrnstandardized questioner was used to collect data on the demographic information and potential risk factors forrnhepatitis B and C. Five to ten milliliters of blood was collected from each study participants for sero-prevalencernstudy. The serum from each study participants was screened for hepatitis B surface antigen and anti-hepatitis Crnantibody by using rapid screening test kits. All positive samples for hepatitis B surface antigen had confirmed for thernpresence of hepatitis B envelop antigen (HBeAg) and hepatitis B nucleic acid (DNA)by laboratory test method ofrnenzyme linked immunosorbant assay (ELISA).In addition, all hepatitis C positive samples had confirmed for thernpresence of hepatitis C nucleic acid (HCV-RNA) by enzyme linked immunosorbant assay test method. Finally,rncollected data were entered into Epi-Data 3.1â€ software and analyzed by statistical software program SPSS versionrn20.0 (SPSS, Chicago, IL, USA).rnResults: in the study period, 248 (95.4% response rate) study participants had administered the questioner properlyrnand gave blood for sero-prevalence study. The overall prevalence rate for of HBV was 2.8 % (CI= 0.7-5.4%) and forrnHCV was 0.8 % (CI=0.3-1.9%). Most (82.8%) study participants had good knowledge of hepatitis B and Crntransmission and preventive strategies. However, only 64% of participants had positive risk perception (attitude) andrnonly 43% of the study participants had good hepatitis preventive practice. The overall prevalence rate forrnoccupational was 56% among participants with in the past three years. Exposure for blood, body fluids, needle stickrnand sharp injuries were 79%, 56%, 27% and 63% respectively. Among all, only 155(62.5%) study participants had arnhistory of anti hepatitis B vaccination and only 65 (25% of the total) was fully vaccinated. Generally, we find thernrisk factor analysis for hepatitis C was very difficult since itsâ€™ sero-prevalence was too small. However, lengths ofrnworking time per week (COR= 9.1 p