Assessment Of Some Hematological Parameters Of Hypertensive Patients In Public Hospitals Of Harar Eastern Ethiopia A Comparative Cross-sectional Study

Background: Hypertension is a major health problem worldwide and it’s associated withrnincreased risk of cardiovascular disease. Even though hypertension has impact on hematologicalrnparameters and alteration of hematological indices may indicate increased risk to cardiovascularrndiseases, the relationship between hematological parameters and hypertension is little studied. rnObjective: To compare hematological parameters between hypertensive patients andrnnormotensive adult groups from January 1 to March 30 at Hiwot Fana specialized university rnhospitals and Jugel hospitals, Harar, eastern Ethiopia. rnMethods: Institutional based comparative cross-sectional study was conducted from January 1rnto March 30 2020 at Jugel and Hiwot Fana hospital, Harar, eastern Ethiopia. Convenient sampling rntechnique was used to recruit 102 hypertensive patients from 2 hospitals and 102 healthy controlsrnfrom blood bank. Participant’s socio-demographic and clinical information were collected usingrnpre-tested semi structured questionnaire. Blood sample was collected and analyzed by BeckmanrnCoulter DxH 500 analyzer for complete blood count. Data was entered and analyzed using SPSSrn20. Independent t-test and Mann Whitney u-test were used for comparison between groups.rnSpearman’s correlation was used for correlation test. P values less than 0.05 was considered thernlevel of significance. rnResult: 102 hypertensive and 102 healthy controls were enrolled in this study. 61.8 % ofrnparticipants were females. The median ± IQR value of WBC, Hgb, HCT, RDW and MPV were rnsignificantly higher in hypertension group compared to apparently healthy normotensive groups.rnAdditionally, RBC, HCT and RDW showed statistically significant positive correlations withrnblood pressure indices (systolic and diastolic). WBC count and RDW were significantly positivelyrncorrelated with Body mass index. Duration of illness in hypertension patients was alsornsignificantly correlated with PLT and MPV. rnConclusion: The median values of WBC, Hgb, HCT, RDW and MPV were significantly higherrncompared to apparently healthy normotensive individuals. Hence, it is important to assessrnhematological parameters for hypertensive individuals which may help to prevent complicationsrnassociated with hematological aberrations. However, further longitudinal studies are required tornunderstand hypertensive associated changes in hematological parameters.

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