Diabetes mellitus is metabolic syndrome that causes disability, early death, and many otherrncomplications like neuropathy, nephropathy, retinopathy, amputation, erectile dysfunction andrncardiovascular disease (Ichinose et. al., 2007). Currently insulin and many synthetic drugs arernused in diabetes treatment. However, these pharmaceutical drugs are too expensive particularlyrnfor sub-Saharan population in addition to their undesirable side effects. The present study wasrnaimed to evaluate antidiabetic effect and toxicity level of A. afra and M. communis which wererncollected from their natural habitat in Bale Zone, around Goba town, 455km southeast of AddisrnAbaba. These plants extracts were also chemically screened for phytochemicals. Air dried aerialrnpart of A. afra and M. communis leaves were separately extracted both with distilled water andrn95% Methanolic. Acute toxicity test was conducted by orally administrating increasing doses ofrnboth plants aqueous extract to healthy Swiss albino mice. Anti diabetic effect of aqueous andrnmethanolic extract of A. afra And M. communis were separately evaluated by administeringrnthese extracts orally to alloxan induced diabetic mice at single dose of 500, 750 and 1000mg/Kgrnbody weight. The results indicate that mean lethal dose (LDrnfor aqueous extract of M.rncommunis and A. afra were 8125mg/Kg and 9833.4mg/Kg respectively. Aqueous extract of M.rncommunis significantly lowered mean blood glucose level of diabetic mice at dose of 500mg/Kgrnby 61.8% (p< 0.003)on the 5rnthrn50)rnhr. The methanolic extract of M. communis also significantlyrnlowered mean blood glucose level by 48% (P < 0.00003) at 1000 mg/kg dose level. Bloodrnglucose level was significantly decreased by 24% (p < 0.005)and 56.9% (p < 0.0004) in groupsrnreceived aqueous extract of A. afra at dose of 500mg/Kg and 750mg/Kg respectively. Thernmethanolic extract of A. afra also significantly lowered blood glucose by 49.8% (p