Protein And Albumin To Creatinine Ratio And Their Loss In Urine Associated With Kidney Diseases.

Abstract rnBackground: Proteinuria is recognized as an independent risk factor for cardiovascular and renalrndisease and as a predictor of end organ damage. Appearance of albumin in the urine is one of thernfirst sign of deteriorated kidney function. As the kidney functions decreases, the amount ofrnalbumin in the urine increases. So, Albumin: Creatinine ratio and/or Protein: Creatinine ratio onrnrandom urine sample provides significant results for quantitating proteinuria againstrnconventional 24-hours sample collection. rnObjective: - To review and recommend the method(s) for quantitating proteinuria using urinaryrnAlbumin: Creatinine ratio and/or Protein: Creatinine ratio on random urine samples vis-a-visrnconventional 24-hours urine collection for diagnostic evaluation of Kidney function. rnMethods: I performed a systematic review of literatures on measurement of Albumin: Creatininernratio and/or Protein: Creatinine ratio on a random urine compared with the conventional 24hoursrnurinerncollectionrnmethod.rnrn rnrn rnResults: Data were extracted from 8 studies which investigating proteinuria in several settings.rnPatient groups in the studied were primarily those with hypertension, diabetic, preeclampsia orrnrenal disease. Urine Microalbumin: Creatinine ratio, Albumin: Creatinine ratio and Protein:rnCreatinine ratio vs. 24-hours urine specimen has correlation coefficients (r>0.84, p

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