Reference Value Determination Of Cd4 T-lymphocyte In Hiv Sero- Negative Ethiopian Pregnant Women

In Ethiopia, reference intervals in clinical laboratories are commonly based on results obtainedrnfor western populations or from test kit manufacturers. The present cross sectional study aimedrnto establish reference interval for CD4rn+rn T lymphocyte counts, in HIV sero-negative pregnantrnwomen attending antenatal care clinic at Yekatit 12 hospital. rnFlow cytometric analysis was performed to determine CD4rn+rn and total T lymphocyte counts.rnAccordingly gestational ages between 4 and 38weeks (n=120) were used. Reference valuesrnobtained were 310-1185 cells/µl for Absolute CD4rn+rn T cells count, 17.9-54.0% for CD4rn T cellsrnpercentage, 690-2540 cells/µl for absolute CD3rn+rn T cells count, 55-84% for CD3rnT cellsrnpercentage, 952-2985 cells/ µl for absolute CD45 rn+rn lymphocyte count. rnThe data revealed that CD4rnabsolute CD4rn+rn+rn T cell percentage was stable throughout the pregnancy period while rn T cell count varies between trimesters indicating that CD4rn+rn T cell percentagerncould be more reliable in the management of HIV infected pregnant women than the absoluternvalue. In conclusion, T lymphocyte populations in pregnant women were different from nonrnpregnant women. The clinical implication of these differences is the initiation of antiretroviralrntherapy (ART) in HIV infected pregnant women.

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