Background: Metabolic syndrome is a serious public health concern that describes a cluster ofrndisorders and is associated with several health problems. The global prevalence of metabolicrnsyndrome has increased dramatically in the past decade, workplace which directly influence thernphysical, mental and social well-being of employees are considered important environmental andrnsocial determinants for risk of metabolic syndrome. Therefore, biochemical profiling of thesernpopulation is required.rnObjectives: This study aimed to assess the association between working environment andrnmetabolic syndrome among workers in Aksum town, central zone, Tigray Region, Ethiopia.rnMethods: A cross sectional study was conducted from September, 2020 to August, 2021 in Aksumrntown. A standard questionnaire was used to collect data on socio-demographic variables.rnBiochemical analysis was done using COBAS C 311 analyzer for the determination of lipid profile,rnfasting blood glucose and anthropometric measurements. The data were interred into SPSSrnversion 25 and binary logistic regression and linear regression were analyzed to evaluate thernassociation between variables. If P. value â‰¤ 0.05, it is considered as statistical significance. rnResult: The findings of this study showed that the magnitude of metabolic syndrome was 16.0%rn(13% government office workers & 3% Daily laborers). The most common metabolic syndromerncomponents among government office workers reduced high-density lipoprotein-cholesterol werern19%, hypertriglyceridemia was 22% & hypertension was 24%, had significant positivelyrnassociated with a higher risk of metabolic syndrome (P< 0.05). Hyperglycemia were 18% andrnabnormality of body mass index was 30% frequently found in government office workers (P >0.05).rnGovernment office workers 35% had less vigorous physical activity level, 38% had less type ofrnolive oil used for cooking & 27% had less than 3 serving of fruits and vegetables per week asrncompared to daily laborers (P< 0.05).rnConclusion: In this study, the prevalence of metabolic syndrome was (16%), 13% of governmentrnoffice workers had a higher comparable to 3% of daily laborers. Metabolic syndrome was morerncommon in government office workers, urban population and with advancing age, by hypertension,rndyslipidemia and central obesity were the most frequent components of metabolic syndrome.