Background:-Burns are one of the most common and devastating forms of trauma globally.rnPatients with burn wounds are at higher risk for infections due to multiple factors. P. aeruginosarnplays a prominent role as an etiological agent involved in serious infections among burn patients,rnwhich varies by geographical location. There is a paucity of information about the specificrnprevalence and antimicrobial resistance patterns of P. aeruginosa among burn patients in Ethiopia. rnObjective:-This study was designed to assess the prevalence and antimicrobial-resistant patternsrnof P. aeruginosa among burn patients attending Yekatit 12 Hospital Medical College in AddisrnAbaba, Ethiopia rnMethods:-Hospital-based cross-sectional study was conducted at Yekatit 12 Hospital MedicalrnCollege among patients attending burn clinic from November, 2020 to April, 2021. Detection andrnidentification of P. aeruginosa were performed using conventional culture, Biochemical tests, andrnGram staining. Antimicrobial resistance testing was done using Kirby-Bauer disc diffusionrnmethod. Logistic regression analysis was computed to determine the associated factors for P.rnaeruginosa infection. rnResults:-From the total of 210 burn wound cultures, 27 (12.86%) were found positive for P.rnaeruginosa. All the isolates showed greater than 70% susceptibility for the tested antibiotics exceptrnGentamycin (29.63%), Ceftazidime (59.3%) and Ciprofloxacin (66.67%). Imipenem was the mostrneffective drug (89%) in inhibiting the growth of P. aeruginosa isolates. In addition, 33.33% of P.rnaeruginosa isolates were Multidrug-resistant (MDR). Admission type, Hospital stay time and totalrnbody surface area (TBSA) had a statistically significant positive association with P. aeruginosarninfection (all with P-value >0.05). rnConclusion:-The overall, prevalence of P. aeruginosa among burn patients in the current study isrnalmost 13%. P. aeruginosa isolates were most sensitive to Imipenem, while they were mostrnresistant to Gentamycin. One-third of P. aeruginosa isolates were multidrug-resistant. Thisrnsuggests the need to improve and monitor the treatment of infection with the pathogen to limit thernpossibility of the emergence of multidrug-resistant isolates in burn treatment centers.