Background: Urinary tract infections (UTIs) are the most infections in renal transplantrnrecipients and it has serious consequences in several countries including Ethiopia. rnObjective: To determine the bacterial and fungal profile, antibacterial drug susceptibilityrnpatterns and risk factors for urinary tract infections caused by bacteria and fungal etiologicalrnagents from urine of kidney transplanted patients at SPHMMC Addis Ababa, Ethiopia. rnMethod: A hospital-based cross-sectional study was conducted from November 2020 to Aprilrn2021. A structured questionnaire was used to collect data on socio-demographic factors andrnclinical conditions. Blood, MacConkey, and brain heart infusion agar were used to culture allrnurine samples. Gram stain, biochemical tests, and chromagar for yeast were used to characterizernall culture positives were done according to the standard technique. All bacterial isolates wererntested for antibiotic susceptibility using the Kirby-Bauer method. The possible risk factors werernassessed using simple and multivariate logistic regressions. rnResults: 63 pathogenic microorganisms were found in 207 clinical specimens. Gram negativernbacteria accounted for 63.5 %, Gram positive bacteria for 23.8% and fungal isolates representedrn12.69 %. The most common bacteria identified in urinary tract infections (UTIs) were E. coli,rnKlebsiella pneumoniae, and Coagulase negative staphylococcus. Candidia krusei and Candidiarnalbicans was among fungal isolates. Multidrug resistances were observed among 82% of Gramnegativernrnbacteria. The highest rates of antimicrobial resistance were observed inrnAminoglycosides and 3rd generation cephalosporins. Carbapenem, Nitrofurantoin, Nalidixicrnacid, Amikacin and Fluoroquinolones were the most effective antibiotic to treat UTIs. rnConclusion: Candidia albicans and Candidia krusie funguria were shown to be prevalent UTIsrnin people who had their kidneys transplanted, according to the study. Bacterial isolates showedrnresistance to commonly used antibiotics. These data are essential for identifying future potentialrnprevention strategies against UTI in kidney transplant recipients, as well as the causal agent,rnrelated factor and antibiotic resistance pattern.