Background:rnBurn injuries are classified as one of the most devastating of all injuries and rnmajor global public health crisis. It is also one of the injuries which have pronounced effects onrnchanging body biological parameters. However, little is known with regard to strategicrnmanagement of burn patients by using an expected alteration of hematological and biochemicalrnparameters in Ethiopia. rnObjectives:rnTo determine selected Hematological and biochemical profile of burn patients atrnYekatit 12 medical hospital and AaBET Hospital, Addis Ababa, Ethiopia from October, 2020 to rnJuly, 2021. rnMethods:rnA prospective cross-sectional study was conducted among 72 burn patients and 71rncontrol groups from October, 2020 to July, 2021 at Yekatit 12 and AaBET medical hospitals,rnAddis Ababa, Ethiopia. Complete blood Count and biochemical assays were performed usingrnBeckman coulter and Roche Diagnostic Cobas C311 automated analyzers respectively. Data wasrnentered, analyzed and interpreted by using SPSS version 24. Association of selectedrnHematological and biochemical profile were done with the severity of burn. Statisticalrnsignificance was defined as p value < 0.05 with 95% confidence interval.rn rn rnResults:rnOf the total 72 burn patients, 37(51.4%) were females and 32(44.4%) were childrenrnaged from 1 to 15 years old. Of the total 71 controls, males were 36(50.7%) and 39(54.9%) werernadults >30 years old. Both burn patients and control groups resided in Urban areas 42(58.3% andrn36(57.7%) respectively. Most injuries were Second degree burn 46(63.9%) caused mainly byrnScald 31(43.1%) with 10-20% Total Body Surface Area (TBSA %) affected in the majority ofrncases (29(40.3%)). The majority of the Scald occurred in young children aged 1-15 years oldrn17(53.1%) Blood WBC count was initially raised and gradually decreased. HGB and HCT levelrnwas low during admission as compared to control group and increased on 1rnstrn and 2rn weeks. RBCrncount was elevated during admission comparing with control and then decreased. Serumrncreatinine and urea levels decreased on admission, 1rnstrn and 3rnrdrnndrn weeks but showed increment on 2rnrnweek. Serum AST levels increased on admission and 3rnrdrn week. But it decreased on 1rnrnweeks. With regard to serum ALT levels, there was a significant increment (p0.05) increment on 1rnst rnweek and 3rnrd rnweek and there was arndecrease on 2rnnd rnweek. In case of serum Narn+rn electrolyte concentration, there was decrement onrnadmission and 1rnstrn week and increased on 2rnndrn and 3rnrdrnstrn weeks. With regard to serum Krnrnconcentration, it decreased on admission and on 3rnrdrn week, but there was an elevation on 1rn andrn2rnndrn weeks. Severity of burn high (TBSA %) had a direct relationship with WBC mean change butrnit was inversely related to platelet mean change. There was slightly high change of biochemicalrnprofile with high TBSA value. rnConclusion:rn Various selected hematological and biochemical changes have been observed inrnburn patients. Thus this finding can be helpful to the health care team to make careful monitoringrnof these hematological and biochemical parameters which can help improve the health of burnrnpatients, reduce mortality rate and improve survival.