Background: A higher risk of thrombocytopenia was identiï¬ed in malaria patients withrnsevere anemia, neurologic complications, pulmonary complications, liver dysfunction,rnrenal impairment and severe hypoglycemia. However, there is limited informationrnregarding platelet parameters abnormality associated with malaria infection in Ethiopia.rnObjective: The objective of this study was to asses platelet count in malaria suspectedrnpatients in Adama Referral hospital, Adama.rnMethod: In this cross-sectional study which was conducted from February to Septemberrn2020, 442 malaria suspected patients were selected using convenient sampling technique.rnData was collected using interviewer administered pre-tested questionnaire and clinicalrndata was obtained from patient medical record. Complete blood count was performedrnusing Beckman Coulter (DXH800) automated hematology analyzer and finger prickrncapillary blood was used for microscopic examination of malaria. Data was entered andrnanalyzed by using (SPSS) version 24. Descriptive statistics was applied to determine thernmean, frequencies, and percentages of the study parameters. Pearson correlation analysisrnand regression analysis was performed to see significance association between variablesrnP value less than 0.05 was considered statistically significant.rnResult: Of the 422 malaria suspects majority 206 were (48.8%)in the age group of 20-40rnand 214 (50.7 %) were females. The overall magnitude of malaria was 23.9% (101/422)which is 56(26.9%) and 45(21.0%) in males and females, respectively. The overallrnmagnitude of thrombocytopenia was 77(18.2%). Among thrombocytopenic patients,rn55(71.4%) were positive for malaria. Magnitude was higher in P. vivax patients. Therernwas negative correlation between parasite density and platelet count (r=-0.539 P=0.01)as well as with neutrophil % (r=-0.374 P=0.01).lymphocyte count % and parasite densityrnhad positive (r= 0.476 P=0.01)lymphocyte count # and parasite density had positiverncorrelation (r=0.236 P=0.05).rnConclusion:The magnitude of thrombocytopenia was higher among malaria positive thanrnnegative patients and it was relatively more common among P. vivax than P. falciparumrninfected patients.