Microbial Profile Drug Susceptibility Pattern And Associated Risk Factor Of Urinary Tract Infection In Intensive Care Unit Patients At Public Hospitals Addis Ababa Ethiopia

Background; Healthcare-associated urinary tract infections are one of the most commonrncomplications in hospitalized patients particularly in intensive care unit patients. Both bacteriarnand yeast, are implicated as the etiological agents of urinary tract infections. rnObjective: To determine the spectrum of the etiology (bacterial and yeast), risk factors, andrnantimicrobial susceptibility patterns of urinary tract infections patients admitted in intensive carernunit in public Hospitals at Addis Ababa Ethiopia. rnMethods: A cross-sectional study was conducted from September 2020 to December 2020 inrnAddis Ababa public Hospitals’ intensive care unit patients. By using convenient samplingrnmethod a total of 220 patients included. To assess Socio-demographic status and associated riskrnfactors of participant we used a structured questionnaire. Urine specimens were collected fromrnstudy participant, sent to Ethiopian public health institution for microbiological investigation andrnantimicrobial susceptibility testing. The data was analyzed by SPSS software version 23. rnResults: Out of 220 urine samples 113 (51.4%) were culture positive of which 20.9% wasrnbacteriuria while 19.1% was candiduria and 11.4% by mixed culture. The most commonrnorganism isolated was Candida albicans 29 (21.01%) followed by Enterococcus spp andrnCandida krusei 18 (13.1%) for each. Ampicillin, Ceftriaxone, and Cefotaxime highly resisted byrnmost Gram-negative bacteria. Amikacin, Meropenem and, Imipenem were the most active drugsrnagainst Gram-negative bacteria. Penicillin is resisted by Gram-positive bacteria whereasrnNitrofurantin best drug of choice for Gram-positive bacteria. Number of admission days inrnIntensive Care Unit, diabetes millets and Injury found to be risk factors for urinary tractrninfection. Female sex, and antibiotic use also a predisposing factor for urinary tract infectionrncaused by yeast. rnConclusion and Recommendation: The overall prevalence of bacteriuria/ candiduria wasrn51.4% with high drug resistance of bacterial isolate. This implies that, UTI is a significantrnproblem in different public Hospitals’ intensive care unit patients in Addis Ababa. Thus,rnHospitals may need revise their infection prevention practices to prevent the transmission ofrnresistant bacteria in Intensive Care Unit.

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