Background: Bacterial infection is one of the most common life-threatening complications of rncancer and cancer treatment. Ureteral tract infection (UTI) has become a serious concern inrncancer patients. Therefore, the present study aimed to determine the spectrum and antibioticrnresistance pattern of bacteria related to urinary tract infections among cancer patients. rnObjective: The study aimed to determine antimicrobial resistance pattern, UTI bacterial profile,rnand their associated risk factors among cancer patients attending Tikur Anbesa Hospital, AddisrnAbaba, Ethiopia. rnMethods: A cross-sectional study was conducted from December 2020 to May 2021 among UTIrnsuspected cancer patients in Tikur Anbesa hospital. Study participants were recruited through arnconvenient sampling technique through consecutive sampling. Socio-demographic variablesrnwere collected using a pre-tested questioner while clinical variables were collected through chartrnreview and physical examinations. A morning midstream urine sample was collected for urinernculture. Colony characterization and species identification, and antimicrobial susceptibility wererncarried out. The data was entered and analyzed using SPSS. Descriptive statistics were presentedrnusing tables and figures. Bivariable and multivariable logistic regression analysis was done tornassess the association between dependent and independent variables. A P-value less than 0.05rnwas considered statistically significant. rnResult: Of the total of 272 urine sample tested , about 20.2% of the study participants werernculture positive for a different type of bacterial pathogens predominantly gram-negativernpathogens outnumber 45 (81.8%). E. coli was the predominant one reported among 26 (47.3%)rnof the patients followed K. pneumonia 9 (16.4%), Enterococcus Spp. 5 (9.1%). Majority of thernisolates were sensitive for gentamycin 69.1%, meropenem 95.6%, nitrofatonin 84%. Incontrast,rnisolates were resistant to ciprofloxacin 90.7%, augmentin 88.9%, and ampicillin 96.4 %. Factorsrnsuch as being female (AOR 7.86, 95% CI (3.45, 17.89)), the presence of additional comorbidityrn(AOR 2.4, 95% CI (1.05, 5.49)), those who had a history of catheterization (AOR 3.61, 95% CIrn(1.04, 12.52)) and symptomatic cancer patients (AOR 3.79 95% CI(1.84, 7.79)) had statisticalrnsignificant association with more likely to develop bacteriuria rnConclusion and Recommendations: Bacteriuria among cancer patients was considerably high.rnBeing female, having a history of catheterization, presence of additional comorbidities, andrnbeing symptomatic have been associated with bacteriuria. E. coli was the predominant bacterialrnisolate. Antimicrobial susceptibility patterns showed that the majority of the isolates werernresistant to commonly used antibiotics such as ciprofloxacin, augmentin, and ampicillin. Thus,rnurine culture is very important for cancer patients to control drug resistance, to restrict and givernonly after doing culture and sensitivity tests.