Changes In Hematological Parameters In Hiv-1 Infected Patients Before And After Antiretroviral Therapy In Tikur Anbessa Specialized Teaching Hospital Art Clinic.

HIV/AIDS is characterized by progressive damage to the body’s immune system that results in arnnumber of opportunistic infections, immunological and hematological complications.rnHematological complications have been documented to be the second most common cause ofrnmorbidity and mortality and are estimated to affect from 11% to 75% of patients with HIVrndisease. They are generally marked with cytopenias such as anemia, neutropenia, lymphopeniarnand thrombocytopenia. These abnormalities may be of greater concern in populations in subSahararnrnAfrica, where comorbidities such as malnutrition, malaria, and parasitic infections arerncommon, and capacity to monitor adverse events related to ART is often limited. Althoughrntreatment of HIV infected patients using ART is accepted as the gold standard, few studies triedrnto assess hematologic responses to ART. rnA comparative cross sectional study was conducted to determine changes in hematologicrnparameters in HIV infected patients before and after ART from July to August 2011 in TASTHrnART clinic. Socio-demographic, baseline hematologic parameters and ART related informationrnof study participants were collected using a structured questionnaire. CBC and CD4+ T cellrncount was done for 340 HIV infected patients by hematological analyzer and FACS count,rnrespectively. The data was entered and analyzed in simple descriptive statistical methods usingrnSPSS window version 16. rnFrom this study, WBC, neutrophils, lymphocyte, hemoglobin and platelet count showedrnincrement from the baseline by mean 0.36 x 10rn3rn/ μL, 0.12 x 10rn3rn/ μL, 0.25 x 10rn/ μL, 0.98 g/dLrnand 20 x 10rn3rn/ μL, respectively after ART. Proportion of leucopenia, neutropenia,rnlymphocytopenia, anemia and thrombocytopenia was dropped from baseline 25.9% to 11.5% (pvalue=rnrn0.000), 23.2% to 17.4% (p-value= 0.057), 24.1% to 9.1% (p-value= 0.000) 45% torn20.88% (p-value= 0.000) and 28.5% to 11.2% (p-value= 0.000), respectively. Nevertheless,rnreduction in mean hemoglobin (p-value= 0.070) and high proportion of anemia (p-value= 0.000)rnwas observed in AZT than non-AZT containing ART treatment. rnIn conclusion, ART was effective in improving blood cell count and decreasing hematologicrnabnormalities in HIV infected patients.

Get Full Work

Report copyright infringement or plagiarism