Background: Gonorrheae is asexually transmitted diseasecaused by the bacteriumNeisseriagonorrhea for which humans are the only natural host. It is fastidiousGram-negative coccitransmitted by human-to-human contact.Gonococcal infectionhighly adapted to the genital tractandoften causingasymptomatic and undetected infection in females in which the highest ratesare found mainly in femaleâ€™sof reproductive age group.There are a number ofantibiotics fortreatment of gonorrhea in which the preferences varywith the local situation.rnObjective: To determine the prevalence and drug susceptibility pattern ofNeisseria gonorrheaamong symptomatic women attending gynecologic OPD in Hawassa Referral Hospital.rnMethods:A cross-sectional study was conducted from December 2010 to February 2011 atHawassa University Referral Hospital Hawassa, Ethiopia. During the study period, all womenpatients visited to gynecologic OPD with suspected of gonococcal infection were included.Theinclusion criteria for the selection of215 women of reproductive age group was based onanysign andsymptoms for STD up on clinical examination ofsymptomaticpatients at gynecologicOPD.Endocervical swab were collectedby the attending physician. The Presence of gonorrheawas confirmed by culture, Gram staining and biochemical tests. Antimicrobial sensitivity test wasperformed using disc diffusion method and the result was interpreted accordingly.rnResult:Of the total 215 patients examined, 11 (5.1%) were confirmed to have gonococcalinfection.The highest prevalence was observed in age group 20-24 which is 5/11 (45.5%) andthere is no statistical significant association(p>0.05).The susceptibilitypatterns weredoneagainst 11 antimicrobial agents by the agar disc diffusion technique. Low level of susceptibilityto quinolones (ciprofloxacin 55%, ofloxacin 64% & lomefloxacin 64%) was reported.rnConclusion:The findings from this study indicate that gonococcal infection was moderatelyhigher combined with highNeisseria gonorrhearesistance.