Assessment Of Malnutrition Using Biochemical Markers Among Female Breast Cancer Patients Attending Tikur Anbessa Specialized Hospital Ethiopia

Introduction: Breast cancer is the most common cancer worldwide. Malnutrition occursrnfrequently in cancer patients.rnMalnourished cancer patient responds poorly to therapeuticrninterventions, such as chemotherapy, radiotherapy and surgery with increased morbidity andrnmortality.rnObjective: The aim of the present study was to evaluate malnutrition in breast cancer patientsrnthrough biochemical markers at Tikur Anbessa Specialized Hospital, Ethiopia.rnMaterials and methods: Hospital based cross-sectional study was conducted in 50 breast cancerrnpatients and 50 healthy individuals from January to April 2017 at Tikur Anbessa SpecializedrnHospital, Ethiopia. The required amount of blood was withdrawn from both group by wellrntrained nurses in the hospital and serum stored at -800c refrigerator until analysis. Data wererncollected on socio demographic factors, biochemical, anthropometric and hematologicalrnparameter.rnResult: The mean age of the study and control group was 43.06 year. Comparison of meanrnbetween study and control group shows 3.89 ± 0.04 g/dl and 4.34 ± 0.17g/dl for albumin, 3.92 ±rn0.08 g/dl and 3.35 ± 0.04 g/dl for globulin, 1.73 x 103 ± 0.29 cells / mm3 and 2.35 x 103 ± 1.12rncells /mmrn3rnfor total lymphocyte count, 0.72 ± 0.03 mg/l and 0.96 ± 0.03 mg/l for creatinine,rn25.19 ± 1.22 mg/l and 21.62 ± 1.01 mg/l for urea for study and control group respectively. Allrnthe above mean values show statistically significant difference between study and control groupsrnwith p value < 0.05. There were no statistically significant difference mean value levels of totalrnprotein and body mass index in our study. Prevalence of malnutrition assessed through albuminrnwas 32%, TLC 46% and BMI 36%. Pearson correlation analysis revealed positive correlationrnbetween globulin and total protein level (r = 0.84, P < 0 .0001) and negative correlation betweenrnalbumin and globulin level (r = -0.48, p < 0.0001) in the breast cancer patients. Albuminrnpositively correlated with TLC (r = 0.51, p= 0.03) in the breast cancer patients.rnConclusion: The present study revealed serum albumin, globulin, creatinine, urea level werernreliable biochemical markers combined with TLC for assessment of malnutrition in breast cancerrnpatients.rnKey words: breast cancer, Malnutrition, Albumin, Globulin, creatinine and total lymphocyternCount

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