Invivo Anti-malarial Evaluation Of Leaf Extract Of Vernonia Amygdalina Del. (asteraceae) Against Plasmodium Berghei

Introduction: Malaria is one of the world’s most serious infectious diseases caused byrnPlasmodium parasites. An increased drug resistance to conventional anti-malarial,rnincreasing resistance of mosquito vectors to insecticides, challenge of having effectivernvaccines and adverse effects of the existing anti-malarial drugs justifies the urgent needrnfor more effective, tolerable and affordable anti-malarial drugs.rnObjective: In the attempt to search for new antimalarial drugs, the present study aimed tornevaluate antimalarial activity and acute toxicity of crude extract of Vernonia amygdalinarnleaf extracts.rnMethods: The leaf of Vernonia amgdalina extract were prepared by cold macerationrntechnique, four day suppressive, curative and prophylaxis test in mouse model was donernto cheek the effect of the plant extracts against Plasmodium berghei in Swiss albino mice.rnExtracts were administered at doses of (200, 400 and 600) mg/kg body weight of mice.rnData obtained from the experiment was analyzed using paired t-test and one wayrnANOVA.rnResults: The present study indicated that the extract did not exhibit any signs of acuterntoxicity up the dose of 2000mg/kg. The aqueous and hydrometanol extracts of V.rnamygdalina showed a parasitemia chemosuppression at the dose of 600 mg/kg with 68.8rnand 69.2 % (p

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