Genetic Study Of Lct- Enhancer Y Chromosome And Mitochondrial Dna Variation In Some Ethnic Groups In Ethiopia

Genetic Study of LCT- Enhancer, Y chromosome and Mitochondrial DNA Variation in Some Ethnic Groups in Ethiopia rnSolomon Balami Adugna (PhD Candidate) rnAddis Ababa University, 2018 rnEthiopia has been the centre of Human out of African migration and thus occupies a strategic place to study of human evolutionary population genetics. It is regarded as a centre where key evolutionary events have taken place; as a place of human origin, a corridor for human migration and centre for origin of earlier human culture. Despite of the importance of Ethiopian population genetics, the human population genetic studies across geographically, ethnically and linguistically diverse Ethiopia population is still not exhaustively covered and understood. To contribute to these, genomic DNA was collected from five ethnic groups of Ethiopia; Nuer, Berta, Gumuz, Shinasha and Mao to examine the correlation of LP phenotype with genotype and study the patterns of Y chromosome and Mitochondrial DNA Variations. From these groups, a total of 155 participants, representing two language families; Afro-Asiatic and Nilo-Saharan in Ethiopia, were recruited for genetic analysis. rnThe phenotypes of the lactase persistence (LP) were examined using breathe hydrogen test (BHT). The result showed that 83 (53.55%) and 68 (43.87%) of the total 155 study subject had a positive breath (≥20 ppm) and negative breath test (

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