Pholiota nameko (T.Ito) S.Ito) is white rot wood inhabiting ligninolytic mushroom speciesrnbelonged to genus Pholiota, widely distributed through out Far East which has been used asrnfood and medicinal purpose. The research experiment was carried out to investigate the yieldrnand the biological efficiency of Pholiota nameko grown on different agro industrial wastes inrnEthiopia. For the cultivation of Pholiota nameko 6 kinds of substrates, namely eucalyptusernshaving (ES), cordia shaving(CAS), coffee husk(CH), Pinus shaving(PS), cotton seed (CS) andrnteff straw(TS) were used as the main material or substrates. Wheat bran (WB) was used anrnadditive material 100:10 and 100:30 w: w of the main material. Moisture content of thernsubstrate was maintained to50-65 %. Only three substrates, these are eucalyptuse shaving (ES),rncotton seed and cordia shaving(CAS) show remakable production of fruiting body. The highestrnmean yield and biological efficiency were 797.33 g, 53.27% respectively on eucalyptuse shavingrnsupplemented with 30% wheat bran. The higher harvest 732.33g, 48.98% mean yield andrnbiological efficiency respectively obtained from cotton seed supplemented with 30 % wheat bran.rnWhile the lowest mean yield and biological efficiency were obtained from Cordia africanarnshaving supplemented with 10% wheat bran 550.8g, 36.80% respectively. There was nornstatistical difference observed between substrates supplemented with 10% and 30% wheat branrnon yield and the biological efficiency. But substrate supplemented with 30% wheat bran showedrna little better quality of fruiting body and cropping time than substrate supplemented with 10%rnwheat bran. In general the yield of Pholiota nameko mushroom harvested was significantlyrn(P