Studies on molluscicidal activity of plants have drawn increasing attention due to such issuesrnas environmental preservation, high cost, and concern over emerging of resistance in snails tornsynthetic molluscicides. In line with this the present study evaluated the molluscicidalrnactivity of aqueous extracts of Balanites aegyptiaca seeds and fruits against adultrnBiomphalaria pfeifferi and Lymnaea natalensis snails as well as the cercariacidal activityrnagainst Schistosoma mansoni. Snail mortalities were compared between each plant part andrnsnail species, and LC50 and LC90 values for the plant parts tested were computed. For thernmolluscicidal activities of seed, endocarp, mesocarp and whole fruit part, the LC50 valuesrnagainst B. pfeifferi were 56.32, 77.53, 65.51 and 66.63 ppm, respectively, while thernrespective LC90 values were 77.70, 120.04, 89.50 and 97.55 ppm. Similarly, the LC50 valuesrnfor the seed, endocarp, mesocarp and whole fruit against L. natalensis were 80.33, 92.61,rn83.52 and 87.84 ppm, respectively, while the respective LC90 values were 102.30, 138.21,rn115.42 and 127.69 ppm. B. pfeifferi were found to be more susceptible to B. aegyptiaca thanrnL. natalensis. As regards the cercariacidal activities of the plant, the in vitro mortality ofrncercariae exposed to aqueous extract of seeds increased with increasing concentration andrnexposure time. Infectivity evaluation test showed that S. mansoni cercariae exposed to 15rnppm of aqueous extract of seeds were incapable of infecting mice. In particular, the mean eggrnload of tissue was reduced in mice infected with the cercariae exposed to 5 and 10 ppmrn(ANOVA, p