Background: Depression is the most frequent comorbid psychiatric disorder in epilepsy. Thernprevalence is 6-30% in developed countries and reaches approximately 50% in developingrncountries, including Ethiopia. There is a bidirectional relationship between depression andrnepilepsy. The seizures themselves or the anticonvulsant drugs can provoke depression inrnpatients with epilepsy. Anti-depression medications can also lower the seizure threshold andrnprovoke seizure.rnObjective: The study was conducted to assess socio-demographic characteristics andrnprevalence of depression in epilepsy and its impact on seizure control among epilepsy patientsrnon follow up at Tikur Anbessa Specialized Hospital and Zewditu Memorial Hospital neurologyrnreferral clinic.rnMethod: A multi-institutional prospective cross-sectional study design was conducted fromrnJune 20, 2020 to October 30, 2020 at Tikur Anbessa Specialized Hospital and ZewditurnMemorial hospital epilepsy follow up clinic. A stratified sampling method was used to collectrndata using a semi-structured questionnaire. The study participants were epilepsy patients whornare on anti-epileptic drug treatment during the study period.The questionnaire comprises ofrnbasic demographic data, clinical variable and PHQ-9. Data analysis was conducted usingrnSPSS version 25, descriptive statistics were used to describe the characteristics of the studyrnparticipants. The results were summarized and described using tables. A logistic regressionrnanalysis was used to assess the association between seizure control and depression and P valuernof