Background and Aims:rnBrain death is defined as irreversible and complete cessation of all brainrnfunction including that of the brainstem. The aim of this study was to assess thernlevel of knowledge, attitude and practice of brain-death declaration amongrnresidents in Tikur Anbessa specialized hospital in the year 2020.rnMethods:rnThis was a hospital based cross-sectional study in which residents from variousrnfield of specialty were included using convenient sampling method. Pretestedrnquestionnaire consisting of questions related to knowledge, attitude andrnperformance of brain-death declaration were distributed among residents as perrnthe inclusion criteria to fill. Statistical tools used were mean and standardrndeviation, and Chi-square test.rnResults: A total 123 residents responded to the questionnaire. About 81{68%}rncorrectly defined it as complete cessation of brain activity including brainstemrnreflexes. Sixty-five {54.6%} of the residents do not agree on brain death to servernto declare legal death .Only 11.7% of the study participants have ever attemptedrnbrain death test.rnConclusion: The majority of the residents know about the definition of brainrndeath but most of them have difficulties in identifying the basic physiologic limitsrnwhich are pre conditions to diagnose brain death. More than half of them don notrnaccept brain death as a legal determinant of death .Practice of brain death testingrnwas poor