Introduction: Job stress is a prevalent problem among nurses working in cancer units as they dealrnwith a large number of patients with various conditions and work overload. Therefore, if it is notrnproperly managed stress leads to high levels of employee illness, absenteeism, high turnover, andrndecreased productivity which compromises the provision of quality service to clients. Coping is arncognitive and behavioral effort one uses to face a stressful situation. There is no recorded data onrnjob stress and coping strategies in our country specifically in the cancer unit. Objective: Tornassess job stress, coping strategy, and associated factors among nurses working in cancer units ofrnselected governmental hospitals at Addis Ababa, Ethiopia, 2020. Method: the institution-basedrncross-sectional study was conducted from March-April 2020. Structured self-administeredrnquestionnaires were used to collect data from the study participant. The study population was allrnnurses who are working in cancer units of selected governmental hospitals in Addis Ababa andrnthe sample size was 124 from three hospitals. The data were entered and analyzed by the SPSSrnwindow software 25 version. Descriptive statistics such as frequency distribution and measure ofrncentral tendency and variability were computed. Bivariate and multiple logistic regressions werernused to identify the association between dependent and independent variables. Result: A total ofrn124 nurses working in the cancer unit of public hospitals were given the questionnaire, and thernresponse rate was 97.6 % (121). The study showed that 52% (63) of nurses had job stressrnwhereas 48% (58) were not stressed. Death and dying, workload, and uncertainty concerningrntreatment are the most sources of stress with average means 2.9, 2.73, and 2.67 respectively.rnIndividual factors like respondentsâ€™ sex (AOR 0.33,95%, CI: 0.167-.0.882) was significantlyrnassociated with job-related stress score. Conclusion and Recommendations, in this crosssectionalrnrnstudy half of the nurses, were occupationally stressful. Individual factors likernrespondentsâ€™ sex were significantly associated with overall job-related stress scores. To preventrnoccupational stress among nurses, policymakers, and different stakeholders should come up withrnstrategies and develop exercise coping mechanisms that will help reduce stress for hospital-basedrnnurses especially in special units like the oncology unit.