Background: Breast cancer is the most common cancer in women worldwide, in 2018rn2.1million new cases are diagnosed. In Ethiopia due to the increasing awareness of breast cancerrnpatients are taking chemotherapy in different parts of the country but patientâ€Ÿs knowledge ofrnchemotherapy and experience of chemotherapy has not assessed very well and this study will tryrnto assess patientsâ€Ÿ knowledge about chemotherapy. rnObjective: the objective of the study is to assess the knowledge and experience of women withrnbreast cancer receiving chemotherapy in selected public hospitals Addis Ababa Ethiopia, 2021. rnMethods: Institutional based cross-sectional study was conducted and data collected from TASHrnand SPHMMC from February 8 to March 1, 2020. Data was entered in to Epi-data version of 4.5rnand export to SPSS version 20.0 descriptive statics such as frequency, percentages, mean andrnstandard deviation were done and displayed in tables. Bivariate and multivariate logisticrnregression analysis was employed. rnResult: the study involved 250 participants. The mean age of the respondents were 43.35 rn.Of the total 135 (54%) respondentâ€Ÿs were not knowledgeable and 115(46%) werernknowledgeable. Age less than 45 years Age >45 years and patients who lived in Addis Ababarnwere associated to higher knowledge. Respondents took chemotherapy fourth to sixth cyclernpatients and who are currently single associated to worst experience and the distance time itrntakes to get to the hospital when it is three to six hours were associated to tolerable experience. rnConclusion and recommendation: The study revealed that more than half of the participantsrnwere not knowledgeable and more than half of the participants had worst experience. Hencernhealth care providers should provide information about chemotherapy to their patients andrnshould teach how to manage the possible side effects